The cells in our bodies are constantly the site of complex cascades of biochemical events. They receive information from the outside and transform it into a biological response. This is called signal or information transduction. When the information is mechanical, it is called mechanotransduction.
Whether under physiological or pathological conditions, mechanical forces are able to stimulate many cells and modify the production of different cellular components, such as extracellular matrix proteins (collagen, elastin, etc.), growth factors, inflammation factors, degradation enzymes and more.
The action of mechanical forces has been extensively studied “in vitro”, and particularly on fibroblasts, keratinocytes or endothelial cells (blood vessel cells). Mechanical stimulation is able to increase the proliferative capacity of fibroblasts through an increase in DNA synthesis, and by stopping the application of such stimulations, DNA synthesis stops. These stimulations induce the transformation of the “normal” fibroblast into a “secreting” fibroblast with an increase in collagen synthesis and inhibition of the enzymes that degrade it.
Also, endothelial cells are sensitive to mechanical stresses exerted by blood flow. Any variation in these stresses results in functional and structural modifications in the vessels. Blood pressure exerts wall tension on endothelial cells, causing the release of growth factors and the migration and proliferation of these cells.
Thus, mechanotransduction mechanisms at the cell level play a fundamental role in the remodelling of tissues and their functionality.
Movement is life, and here’s more proof! When movement is lacking, our tissues sometimes need a boost to get back on track! The stress of life, illness, accident, transient fatigue, ageing and a desire for beauty are all moments when transduction is disturbed, slowed down. Fibrosis, stasis, overload, so many moments when we need a boost!
When our cells lack information to function properly, endermologie is there to provide it by producing a healthy, physiological and tailored mechanotransduction. Induced by LPG proprietary mechanical stimulation methods, the mechanotransduction triggers cellular reactions where there is a deficit or excess. These reactions generate new molecular processes that lead to the restoration of tissue’s mechanical qualities needed to achieve life goals of being healthier, doing sport without risk, enjoying leisure activities, feeling good about oneself and being beautiful! All these results have been demonstrated in the many studies conducted by LPG in the areas of health, beauty, sports and well-being:
■ Adipocytes release fat
■ Lymphatic output increases
■ Fibroblasts secrete
■ Fibrosis becomes deconstructed
■ The extracellular matrix becomes organised
■ Inflammation is controlled
■ Blood flow is accelerated
■ Toxins are eliminated…
endermologie® is to tissue, what the switch is to light: it turns on or off, it stimulates or soothes, strengthens or relaxes! Connective tissue, epithelial tissue, muscle tissue and nerve tissue, all these tissues benefit from this therapy!
As a reminder, mechanobiology is the science that studies the influence of mechanical forces on biological tissue, like skin and bones, and also on cells.
SOURCES :
Evidence of skin changes induced by the LPG® Technique via image analysis. D. Innocenzi, A. et al. DermoCosmetologia- anno II, 1– gennaio/marzo 2003; 9 -15. The other tissue therapy. Jocelyne Rolland. Health News LPG 2006
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